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Research

AST Metastasis Research Center

AST in METASTASIS

  • Aim 01 | AST Paradigm & AST Factor Research

    1. Discover AST Paradigm in reprogramming anchorage dependency of cancer cells
    2. Establish novel cell-based assay and preclinical models for AST-based CTC research
    3. Elucidate the molecular network of AST factors in circulating and disseminated tumor cells

  • Aim 02 | AST Theranostics & Multi-omics Approaches

    1. Discover novel CTC biomarkers linked to AST-based therapeutics for metastasis treatment
    2. Generation of biobank and multi-omics analysis of paired cancer patient samples
    3. Elucidate [epi]genetic landscapes, signal transductions, and metabolic rewiring via AST factors

  • Aim 03 | AST Precision Medicine & Clinical Relevance

    1. In vivo relevance of AST paradigm in metastatic cancer patients and preclinical models
    2. Provide clinical guidance of AST-based molecular classification for metastatic cancer patients
    3. Patient-derived research for clinical application of AST paradigm in treatment and prognosis

  • Aim 04 | ASTatic Therapeutics & Biomarkers

    1. Identification of AST structural network to design small molecule inhibitors
    2. Preclinical validation of ASTatic inhibitors to block dissemination, metastasis and cancer death
    3. Demonstrate efficacy of AST-based liquid biopsy and biomarkers to treat metastatic outcomes

Yonsei University

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